Rh-catalyzed synthesis of helically chiral and ladder-type molecules via [2+2+2] and formal [2+1+2+1] cycloadditions involving C-C triple bond cleavage

We have developed highly enantioselective synthesis of functionalized helically chiral molecules via a Rh-catalyzed [2 + 2 + 2] cycloaddition and synthesis of ladder-type molecules via an unprecedented Rh-catalyzed formal [2 + 1 + 2 + 1] cycloaddition involving C-C triple bond cleavage.