Journal
ORGANIC LETTERS
Volume 9, Issue 21, Pages 4251-4253Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol701811z
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Functionalized gem-difluoro beta- and gamma-lactams were synthesized through a novel intramolecular hydroamination reaction of difluoropropargyl amides.beta-Lactams were obtained via a Baldwin disfavored 4-exo-digonal cyclization using palladium acetate as the catalyst, whereas gamma-lactams were produced under basic conditions. Acid hydration of gamma-lactams produced ketoamides or hemiaminals selectively.
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