Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 282, Issue 41, Pages 29919-29926Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M611539200
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Funding
- NCI NIH HHS [P50 CA 083639, CA110793, CA109298] Funding Source: Medline
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Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro- angiogenic cytokine, interleukin 6 ( IL6), are known to be elevated in individuals experiencing chronic stress, but the mechanism( s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL- 6mRNAand protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL- 6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression.
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