Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 362, Issue 1, Pages 1-4Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.07.166
Keywords
Ryanodine receptor; calsequestrin; triadin; striated muscle; excitation-con traction coupling; calcium signaling
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The single genomic locus, A beta H-J-J, encodes three functionally distinct proteins aspartyl beta-hydroxylase, junctin and junctate by alternative splicing. Among these three proteins, junctin and junctate could play important roles in the regulation of intracellular Ca2+ by regulating either Ca2+ release from intracellular Ca2+ stores or Ca2+ influx in various biological processes. Here we review recent findings concerning the expressional regulations and the proposed functions of junctin and junctate. (c) 2007 Elsevier Inc. All rights reserved.
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