Journal
ANAEROBE
Volume 21, Issue -, Pages 9-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2013.03.003
Keywords
Bifidobacteria; Probiotic; Intestinal adhesion; Pathogen inhibition
Categories
Funding
- Laboratory of Probiogenomics
- Fondazione Cariparma
- FEMS Advanced Fellowship
- IRCSET Embark postdoctoral fellowship
- Science Foundation Ireland (SFI), through the Irish Government's National Development Plan [02/CE/B124, 07/CE/B1368]
- CSIC [I-LINK2010-0122]
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Bifidobacteria are extensively exploited by the food industry as health-promoting microorganisms. However, very little is known about the molecular mechanisms responsible for these beneficial activities, or the molecular players that sustain their ability to colonize and persist within the human gut. Here, we have investigated the enteric adaptation features of the gut commensal Bifidobacterium bifidum PRL2010, originally isolated from infant feces. This strain was able to survive under gastrointestinal challenges, while it was shown to adhere to human epithelial intestinal cell monolayers (Caco 2 and HT-29), thereby inhibiting adhesion of pathogenic bacteria such as Escherichia cod and Cronobacter sakazakii. (C) 2013 Elsevier Ltd. All rights reserved.
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