Journal
CELL CYCLE
Volume 6, Issue 20, Pages 2440-2444Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.6.20.4786
Keywords
GAP; MAP kinase; Rac; Rho; EGF; chimerin; chimaerin
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The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta 2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.
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