Journal
BIOINFORMATICS
Volume 23, Issue 20, Pages 2797-2799Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btm424
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Funding
- NIGMS NIH HHS [GM068152] Funding Source: Medline
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Minocycline, a broad spectrum antibiotic, has been discovered to have inhibitory activity against HIV-1 in vitro, but the targets inhibited are unknown. We used a docking with dynamics protocol developed by us to predict the binding affinities of minocycline against seven active sites of five HIV-1 proteins to putatively identify the potential target(s) of minocycline. The results indicate that minocycline has the highest predicted binding affinity against HIV-1 integrase.
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