Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 196, Issue 8, Pages 1163-1166Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/521625
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The Kaposi sarcoma-associated herpesvirus ( KSHV)-DNA level was determined in samples from 71 patients with Kaposi sarcoma (KS), 28 patients with multicentric Castleman disease (MCD), and 8 patients with primary effusion lymphoma (PEL). KSHV-DNA levels were higher in patients with active KS or MCD than in those with KS or MCD in remission. Among patients with active disease, the highest KSHV-DNA levels were observed in effusion fluid samples from patients with PEL (7.2 log 10 copies/150,000 cells), followed by blood samples from patients with MCD and PEL (4.86 and 3.83 log 10 copies/150,000 cells, respectively), and the lowest levels were observed in blood samples from patients with KS (2.63 log 10 copies/150,000 cells). Determining the KSHV-DNA level may be useful in diagnosing KSHV-associated disease and for following up patients with KS when the development of MCD or PEL is suspected.
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