Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 156, Issue 1, Pages 69-74Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2006.12.012
Keywords
dopamine; D-2 receptor; PET; anterior cingulate; executive function; WCST
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The objective was to investigate the association between extrastriatal dopamine D-2/D-3 receptor binding and performance on the Wisconsin Card Sorting Test (WCST), a measure of executive functioning. Thirty-two healthy volunteers performed the WCST and underwent positron emission tomography and a high-affinity D2/D3 receptor tracer, [C-11]FLB 457. All WCST error parameters, in particular nonperseverative errors, correlated positively with [C-11]FLB 457 binding in the cognitive division of the right anterior cingulate cortex. An independent voxel-based receptor parametric mapping analysis confirmed these findings. The results indicate that executive functioning in healthy volunteers is modulated by D2/D3 receptors in the anterior cingulate cortex. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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