Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 98, Issue 3, Pages 525-534Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/bit.21434
Keywords
chloroperoxidase; Caldariomyces fumago; electroenzymatic synthesis; electrochemical cell; chiral sulfoxide
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The electrogeneration of hydrogen peroxide via reduction of dissolved oxygen was carried out in a three; dimensional electrochemical cell using graphite grains as cathode material and combined with the enantioselective oxidation of thioanisole to (R)-methylphenylsulfoxide catalyzed by Chloroperoxidase from Caldariomyces fumago. The relevant parameters for process development (e.g., conductivity of the biotransformation medium) were identified and optimized, leading to an efficient electroenzymatic process with a space-rime yield of 104 g.L(-1).d(-1). The isolated product was produced on gram scale (1.2 g, purity >98%, ee > 98.5%).
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