Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 20, Pages 5548-5551Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.08.024
Keywords
farnesyl; protein modification; protein farnesyltransferase; peptide synthesis; fluorescence assay
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Funding
- NCI NIH HHS [R56 CA078819, R01 CA078819, R01 CA078819-05A2, P30CA21368, CA78819] Funding Source: Medline
- NIGMS NIH HHS [GM40602, R01 GM040602-18A1, R01 GM040602, T32 GM145304] Funding Source: Medline
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Farnesylation, catalyzed by protein farnesyltransferase (FTase), is an important post-translational modification guiding cellular localization. Recently predictive models for identifying FTase substrates have been reported. Here we evaluate these models through screening of dansylated-GCaaS peptides, which also provides new insights into the protein substrate selectivity of FTase. (c) 2007 Elsevier Ltd. All rights reserved.
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