Journal
GENE
Volume 401, Issue 1-2, Pages 165-171Publisher
ELSEVIER
DOI: 10.1016/j.gene.2007.07.012
Keywords
proteome; bim-gamma; bim-beta 3; Alu; evolution
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Transposable elements (TEs) and their contributions to protein-coding regions are of particular interest. Here we searched for TE fragments in Homo sapiens at both the transcript and protein levels. We found evidence in support of TE exonization and its association with alternative splicing. Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs. Analyses of two Bcl-family proteins and Alu-encoded segments suggest the coding and functional potential of TE sequences. (c) 2007 Elsevier B.V All rights reserved.
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