Journal
VACCINE
Volume 25, Issue 42, Pages 7339-7353Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.08.020
Keywords
HCV; MVA; vaccine
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We designed and evaluated in HLA-class I transgenic mouse models a hepatitis C virus (HCV) T cell-based MVA vectored vaccine expressing three viral antigens known to be targets of potent CD8+- and CD4+-mediated responses. An accelerated (3 week-based) vaccination induced specific CD8+ T cells harboring two effector functions (cytolytic activity - both in vitro and in vivo - and production of IFN gamma) as well as specific CD4+ T cells recognizing all three vaccine antigens. Responses were long lasting (6 months), boostable by a fourth MVA vaccination and in vivo cross-reactive as demonstrated in a surrogate Listeria-based challenge assay. This candidate vaccine has now moved into clinical trials. (c) 2007 Elsevier Ltd. All rights reserved.
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