Journal
FEBS LETTERS
Volume 581, Issue 25, Pages 4884-4890Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.09.018
Keywords
aquaporins; AQP4; membrane protein; olfaction
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Aquaporin-4 (AQP4) has been reported to be upregulated post-partum in pregnancy and in early lung development. Several technical challenges exist in measuring AQP4 protein levels, among them sensitivity to detergent solubilization, sample heating and gel composition. Here we have optimized quantification of AQP4 using immuno-blots. Using improved methodology we find no evidence for AQP4 upregulation post-partum or in the early lung development. However, in the nasal epithelium AQP4 is upregulated as early as in the brain. Furthermore, AQP4 is strongly expressed in the glomerulus, the synaptic unit of the olfactory bulb, suggesting a role for AQP4 in olfactory function. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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