Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 42, Pages 16438-16443Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0701014104
Keywords
cis-regulatory module; transcriptional regulation
Categories
Funding
- NIGMS NIH HHS [GM067250, R01 GM067250] Funding Source: Medline
Ask authors/readers for more resources
We analyze new and existing expression and transcription factor-binding data to characterize gene regulatory relations in mouse ES cells (ESC). In addition to confirming the key roles of Oct4 Sox2, and Nanog, our analysis identifies several genes, such as Esrrb, Stat3,Tcf7, Sall4, and LRH-1, as statistically significant coregulators. The regulatory interactions among 15 core regulators are used to construct a gene regulatory network in ESC. The network encapsulates extensive cross-regulations among the core regulators, highlights how they may control epigenetic processes, and reveals the surprising roles of nuclear receptors. Our analysis also provides information on the regulation of a large number of putative target genes of the network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available