Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 21, Pages 5183-5192Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm070528f
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Funding
- NCI NIH HHS [CA-99957] Funding Source: Medline
- NCRR NIH HHS [RR-16480] Funding Source: Medline
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Podophyllotoxin has been extensively used as a lead agent in the development of new anticancer drugs. On the basis of the previously reported simplified 4-aza-2,3-didehydro podophyllotoxin analogues, we implemented a bioisosteric replacement of the methylenedioxybenzene subunit with a pyrazole moiety to afford tetracyclic dihydropyridopyrazoles. Libraries of these structurally simple analogues are prepared by a straightforward one-step multicomponent synthesis and demonstrated to display antiproliferative properties in a number of human cancer cell lines. These new heterocycles potently induce apoptosis in cancerous Jurkat cells even after a short 24 h exposure. In contrast, no apoptosis is detected in primary lymphocytes under the same treatment conditions. The ease of synthesis and encouraging biological activities make the presented library of dihydropyridopyrazoles promising new leads in anticancer drug design.
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