Journal
ADVANCED MATERIALS
Volume 19, Issue 20, Pages 3377-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200700092
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A protein-based dynamic hydrogel was generated via photo-crosslinking of an engineered protein-polymer conjugate. The protein calmodulin was used in this study due to its pronounced hinge motion in the presence of a variety of ligands. The resulting hydrogel is capable of undergoing substantial (>65%) and controllable volume transitions in the presence of calmodulin ligands, and the change can be attributed to a shift in protein conformation upon ligand binding.
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