Journal
ADVANCED MATERIALS
Volume 19, Issue 20, Pages 3214-3228Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200700665
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Funding
- NIEHS NIH HHS [R01 ES013557, R01 ES013557-02] Funding Source: Medline
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The unique electronic and optical properties of carbon nanotubes, in conjunction with their size and mechanically robust nature, make these nanomaterials crucial to the development of next-generation biosensing platforms. In this Review, we present recent innovations in carbon nanotube-assisted biosensing technologies, such as DNA-hybridization, protein-binding, antibody-antigen and aptamers. Following a brief introduction on the diameter- and chirality-derived electronic characteristics of single-walled carbon nanotubes, the discussion is focused on the two major schemes for electronic biodetection, namely biotransistor- and electrochemistry-based sensors. Key fabrication methodologies are contrasted in light of device operation and performance, along with strategies for amplifying the signal while minimizing nonspecific binding. This Review is concluded with a perspective on future optimization based on array integration as well as exercising a better control in nanotube structure and biomolecular integration.
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