Journal
JOURNAL OF CELL BIOLOGY
Volume 179, Issue 2, Pages 183-186Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200705106
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Funding
- NCI NIH HHS [P01-CA92584, R37 CA050519, P01 CA092584, 5-R37-CA050519-16] Funding Source: Medline
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The DNA- dependent protein kinase ( DNA- PK) is one of the central enzymes involved in DNA double- strand break ( DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest. ndings on DNA- PK phosphorylation and offer a working model for the regulation of DNA- PK during DSB repair.
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