Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 43, Pages 17022-17027Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0708469104
Keywords
colitis; toll-like receptor 9; IFN-1
Categories
Funding
- NIAID NIH HHS [R01 AI068685, AI 68685, R01 AI057709, AI 40682, P01 AI040682, AI 57709] Funding Source: Medline
- NIDDK NIH HHS [DK 35108, P01 DK035108] Funding Source: Medline
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We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.
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