4.8 Article

A new approach to enantiopure inherently chiral calix[4]arenes: Determination of their absolute configurations

Journal

ORGANIC LETTERS
Volume 9, Issue 22, Pages 4447-4450

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol701714q

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[GRAPHICS] A new approach to the synthesis of meta-substituted enantiopure inherently chiral calix[4]arenes by introducing L-Boc-proline as dual functions of the chiral auxiliary has been described. Moreover, the absolute configurations of the enantiomers were determined by CD spectra, X-ray crystallographic analysis, and the chemical derivative method.

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