Journal
ORGANIC LETTERS
Volume 9, Issue 22, Pages 4407-4410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol701570c
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[GRAPHICS] A variety of secondary amines have become utilized in the Ugi reaction by using aminoborane 1 as an iminium ion generator. Aldehydes, secondary amines, and isocyanides are coupled in the presence of 1 at room temperature, giving the corresponding alpha-amino amides in good yields. The nonacidic reaction conditions are beneficial for unique chemoselectivity, where the aldimine functionality is left intact in the present Ugi-type reaction.
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