4.8 Article

Aminocarbonylation of aryl halides using a nickel phosphite catalytic system

Journal

ORGANIC LETTERS
Volume 9, Issue 22, Pages 4615-4618

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol702058e

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Funding

  1. National Research Foundation of Korea [과06B1512] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The nickel and phosphite catalytic system with sodium methoxide enables a very efficient aminocarbonylation reaction to be performed between aryl iodides or bromides and N,N-dimethylformamide (DMF). Phosphite ligand 1, which is very stable to air and moisture and, furthermore, inexpensive, afforded the highest reaction yield.

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