Journal
NEURON
Volume 56, Issue 2, Pages 312-326Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2007.10.003
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Funding
- NEI NIH HHS [R01 EY 013613, R01 EY013613] Funding Source: Medline
- NICHD NIH HHS [P01 HD 18655, P30 HD018655] Funding Source: Medline
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Visual system circuitry, a canonical model system for the study of experience-dependent development, matures before and following the onset of vision. Sensory experience or deprivation during an early critical period results in substantial plasticity and is a crucial factor in establishing the mature circuitry. In adulthood, plasticity has been thought to be reduced or absent. However, recent studies point to the potential for change in neuronal circuits within the mature brain, raising the possibility that aberrant circuit function can be corrected. In this review, we will discuss recent exciting findings in the field of experience-dependent plasticity that advance our understanding of mechanisms underlying the activation, expression, and closure of critical periods in the visual system.
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