Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 22, Pages 8535-8538Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo0712289
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Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free primary amine on the aryl halide.
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