Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 204, Issue 11, Pages 2747-2757Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20062610
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Funding
- NHLBI NIH HHS [T32HL07195-30, T32 HL007195] Funding Source: Medline
- NIAID NIH HHS [R01 AI074074, R01AI074074] Funding Source: Medline
- NIGMS NIH HHS [R01 GM065230, R01GM065230] Funding Source: Medline
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T cells are extremely sensitive in their ability to find minute amounts of antigenic peptide in the midst of many endogenous peptides presented on an antigen-presenting cell. The role of endogenous peptides in the recognition of foreign peptide and hence in T cell activation has remained controversial for CD8(+) T cell activation. We showed previously that in a CD8(+) T cell hybridoma, nonstimulatory endogenous peptides enhance T cell sensitivity to antigen by increasing the coreceptor function of CD8. However, others were not able to detect such enhancement in naive and activated CD8(+) T cells. Here, we show that endogenous peptides substantially enhance the ability of T cells to detect antigen, an effect measurable by up-regulation of activation or maturation markers and by increased effector function. This enhancement is most pronounced in thymocytes, moderate in naive T cells, and mild in effector T cells. The importance of endogenous peptides is inversely proportional to the agonist activity of the stimulatory peptide presented. Unlike for CD4(+) T cells, the T cell receptor of CD8(+) T cells does not distinguish between endogenous peptides for their ability to enhance antigen recognition.
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