Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 204, Issue 11, Pages 2553-2559Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20070254
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T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included ( positive selection) or excluded ( negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes.
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