Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 204, Issue 11, Pages 2505-2512Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20071261
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Funding
- Medical Research Council [G0501963] Funding Source: Medline
- NCRR NIH HHS [RR020141-01, RR15459 01, R24 RR015371, C06 RR020141, P51 RR000167, C06 RR015459] Funding Source: Medline
- NIAID NIH HHS [R01 AI052056, R01 AI049120] Funding Source: Medline
- NIGMS NIH HHS [R01 GM043940, R01 GM043940-17] Funding Source: Medline
- MRC [G0501963] Funding Source: UKRI
- Medical Research Council [G0501963] Funding Source: researchfish
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Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17(+) simian immunodeficiency virus (SIV) mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8(+) T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus-specific cellular immune response is likely far more complex than is generally assumed.
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