Journal
STATISTICS IN MEDICINE
Volume 26, Issue 24, Pages 4386-4399Publisher
WILEY
DOI: 10.1002/sim.2869
Keywords
covariate; log-odds ratio; optimality; two-stage allocation
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In the present work, we develop a two-stage allocation rule for binary response using the log-odds ratio within the Bayesian framework allowing the current allocation to depend on the covariate value of the current subject. We study, both numerically and theoretically, several exact and limiting properties of this design. The applicability of the proposed methodology is illustrated by using some data set. We compare this rule with some of the existing rules by computing various performance measures. Copyright (C) 2007 John Wiley & Sons, Ltd.
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