Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 44, Pages 11925-11933Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1627-07.2007
Keywords
transgenic; stem cells; neuronal death; functional recovery; memory; ablation
Categories
Funding
- NIGMS NIH HHS [GM08620] Funding Source: Medline
Ask authors/readers for more resources
Neuronal loss is a major pathological outcome of many common neurological disorders, including ischemia, traumatic brain injury, and Alzheimer disease. Stem cell-based approaches have received considerable attention as a potential means of treatment, although it remains to be determined whether stem cells can ameliorate memory dysfunction, a devastating component of these disorders. We generated a transgenic mouse model in which the tetracycline-off system is used to regulate expression of diphtheria toxin A chain. After induction, we find progressive neuronal loss primarily within the hippocampus, leading to specific impairments in memory. We find that neural stem cells transplanted into the brain after neuronal ablation survive, migrate, differentiate and, most significantly, improve memory. These results show that stem cells may have therapeutic value in diseases and conditions that result in memory loss.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available