Journal
HAEMATOLOGICA
Volume 92, Issue 11, Pages 1565-1568Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11220
Keywords
FLT3; D-HPLC; MLL rearrangements; hyperdiploid ALL; mutation
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Funding
- Sophia Foundation for Medical Research (SSWO grant) [296]
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MLL rearranged and hyperdiploid acute lymphoblastic leukemia (ALL) are characterized by high-level FLT3 expression and constitutive FLT3 activation. As known activating FLT3 mutations are often absent in these patients, we screened the entire FLT3 coding sequence in MLL rearranged and hyperdiploid ALL cases for yet unidentified additional genetic alterations using denaturing D-HPLC. Both in MLL rearranged and hyperdiploid ALL we found that a small minority of samples, 7% and 10% respectively, carried genetic alterations. Although some of these alterations may induce FLT3 activation, the majority of these patients carry wild-type FLT3 genes.
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