Journal
HAEMATOLOGICA
Volume 92, Issue 11, Pages 1576-1578Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11503
Keywords
JMML; NRAS mutation; blastic crisis; LOH; mitotic recombination
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Funding
- Ministry of Education of Japan [11390300]
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In a patient with juvenile myelomonocytic leukemia, a NRAS mutation at codon 12 (GGT>TGT) was initially heterozygous, but became homozygous after blastic crisis (BC). According to microsatellite and FISH analyses, the post-BC homozygous mutation might result from the loss of the wild-type NRAS locus through mitotic recombination.
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