Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 43, Pages 12936-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja075469+
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Funding
- NHLBI NIH HHS [N01-HV-28185, N01HV28185] Funding Source: Medline
- NIH HHS [DP1 OD000663, DP1 OD000663-03] Funding Source: Medline
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This study describes the identification of the protein target of the first chemical inhibitor (RIP-1) of t he 19S regulatory particle (RP) of the 25S proteasome. Periodate-triggered chemical cross-linking of DOPA-conjugate RIP-1 and the 26S proteasome identified Sug2/Rpt4, one of the six ATPases in the 19S as the molecular target of RIP-1 for Sug2/Rpt4 was domonstarated by examining cross-linking reactions with each ATPase if tge 19S RP. RIP-1 should provide a useful biological tool to probe the various biological roles of Sug2/Rpt4.
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