Journal
HAEMATOLOGICA
Volume 92, Issue 11, Pages 1549-1552Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11576
Keywords
sickle cell disease; pulmonary hypertension; tricuspid regurgitant jet velocity; hemolysis; lactate dehydrogenase
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Tricuspid regurgitant jet velocity (TRJV) >= 2.5 m/sec. on echocardiography is a surrogate marker for pulmonary hypertension (PHT) in adults with sickle cell disease (SCD). We prospectively examined the relationship between TRJV and laboratory markers of hemolysis in 51 children and young adults with SCD at baseline. We found significant correlations between TRJV and lactate dehydrogenase (LDH), hemoglobin (Hb), reticulocyte count (retic) and aspartate aminotransferase (AST). LDH, retic and AST were significantly higher and Hb was lower in subjects with TRJV >= 2.5 m/sec. We conclude that hemolysis significantly contributes to TRJV elevation in children and young adults with SCD.
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