Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 44, Pages 11960-11965Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3591-07.2007
Keywords
Williams syndrome; visuospatial construction; superior longitudinal fasciculus; diffusion tensor imaging; developmental disabilities; genetics
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Funding
- NICHD NIH HHS [P01 HD033113, P01 HD033113-12, P01 HD020806] Funding Source: Medline
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We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups ( typically developing and developmentally delayed) and using three separate analysis methods ( whole brain, region of interest, and fiber tractography). All analysis methods consistently showed that fractional anisotropy ( FA; a measure of microstructural integrity) was higher in the right superior longitudinal fasciculus (SLF) in WS compared with both control groups. There was a significant association with deficits in visuospatial construction and higher FA in WS individuals. Comparable increases in FA across analytic methods were not observed in the left SLF or the bilateral inferior longitudinal fasciculus in WS subjects. Together, these findings suggest a specific role of right SLF abnormality in visuospatial construction deficits in WS.
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