Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 389, Issue 5, Pages 1633-1638Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1558-7
Keywords
antibiotic resistance; beta-Lactamase; Escherichia coli; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Ask authors/readers for more resources
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was optimized to discriminate between wild-type and ampicillin-resistant Escherichia coli. Only ampicillin-resistant E. coli displayed an m/z approximate to 29,000 peak, which was confirmed as beta-lactamase by in-gel digestion followed by peptide mass fingerprinting. Rapid MALDI-TOF MS detection of antibiotic-resistance could fulfill an important clinical need, providing critical phenotypic information beyond genus-species identification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available