Journal
AMYOTROPHIC LATERAL SCLEROSIS
Volume 12, Issue 6, Pages 464-465Publisher
INFORMA HEALTHCARE
DOI: 10.3109/17482968.2011.584195
Keywords
Glycopyrrolate; sialorrhoea; amyotrophic lateral sclerosis; non-invasive ventilation
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Funding
- National Institute for Health Research [ACF-2008-04-003] Funding Source: researchfish
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Sialorrhoea is a recognized complication of bulbar amyotrophic lateral sclerosis (ALS) that leads to an increased risk of potentially harmful aspiration and often prevents patients from tolerating non-invasive ventilation (NIV). A case of treatment-resistant sialorrhoea in bulbar ALS is described where subcutaneous glycopyrrolate was effective without significant side-effects. The patient went on to markedly increase the length of time she could tolerate NIV each night.
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