Journal
AMYOTROPHIC LATERAL SCLEROSIS
Volume 11, Issue 6, Pages 555-557Publisher
INFORMA HEALTHCARE
DOI: 10.3109/17482968.2010.513053
Keywords
Amyotrophic lateral sclerosis; motor neuron disease; microbleeds; blood-brain barrier
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Funding
- Netherlands ALS Foundation
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There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age-and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.
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