Journal
AMERICAN JOURNAL OF RHINOLOGY
Volume 21, Issue 6, Pages 702-705Publisher
OCEAN SIDE PUBLICATIONS INC
DOI: 10.2500/ajr.2007.21.3107
Keywords
acquired ciliary dyskinesia; cilia; diagnosis; Kartagener's syndrome; mucociliary transport time; nasal scraping; primary ciliary dyskinesia; transmission electron microscope
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Background: Primary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease caused by abnormal structure and/or function of cilia. Kartagener's syndrome is one subgroup of PCD. Acquired ciliary dyskinesia is frequent, generally being associated with or following respiratory tract infections. Methods: From January 2003 to April 2006, nasal mucociliary transport time was measured in 64 patients and specimens obtained by nasal scraping were examined by transmission electron microscope (TEM). Results: The 64 nasal scrapings led to the diagnosis of 11 (17.2%) cases of PCD and 51 (79.7%) cases of secondary ciliary disorder. In two cases (3.1%) no clear diagnosis was possible. Conclusion: Nasal scraping is an easy, cheap, and efficient tool for detecting ciliary abnormalities by TEM and for distinguishing acquired and congenital modifications.
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