Journal
AMYOTROPHIC LATERAL SCLEROSIS
Volume 10, Issue 1, Pages 1-14Publisher
INFORMA HEALTHCARE
DOI: 10.1080/17482960802585469
Keywords
Genetics; association; linkage; genome-wide association; copy number variation
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Funding
- Motor Neurone Disease Association and the Medical Research Council
- Medical Research Council [G0600974] Funding Source: researchfish
- MRC [G0600974] Funding Source: UKRI
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The genetic causes of amyotrophic lateral sclerosis (ALS) are slowly being dissected out with the help of recent advances in genetic technology. Linkage studies and association studies examining candidate genes, candidate pathways, and genome-wide association have been used, based on direct sequencing and correlations between genetic variations. Copy number and microsatellite variants have also been examined, although the ideal methods for analysis are still being developed. In this review we examine the evidence for a genetic basis to ALS, discuss the challenges and difficulties faced and summarize the support for the reported genetic causes of ALS.
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