Journal
PSYCHOSOMATIC MEDICINE
Volume 69, Issue 9, Pages 932-934Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PSY.0b013e31815aaa42
Keywords
neuroticism; depression; negative affect; eicosapentaenoic; docosahexaenoic
Categories
Funding
- NHLBI NIH HHS [P01 HL040962, R21 HL081282] Funding Source: Medline
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Objective: To examine the concentrations of omega-3 and (omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. Methods: A total of 116 adults without current Axis I psychopathology completed the Beck Depression Inventory (BDI) and the NEO Personality Inventory-Revised (NEO-PI-R). Fasting serum phospholipid eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid (AA) were determined (% of total pool). Results: Higher AA and AA:EPA ratio, adjusted for age, gender, and race, were associated with greater depressive symptomatology (BDI score of ! 10). Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each associated with two or more fatty acid measurements. Conclusions: In conjunction with other reports, these findings suggest that the (omega-3 and w-6 fatty acids are related to negative affect at both the symptom and trait levels.
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