Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 389, Issue 6, Pages 1997-2002Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1602-7
Keywords
hydrophilic interaction chromatography; liquid chromatography-tandem mass spectrometry; Takifugu oblongus; tetrodotoxin; zwitterionic hydrophilic interaction chromatography column
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Tetrodotoxin (TTX) and its analogs (TTXs), widely distributed among marine as well as terrestrial animals, induce dangerous intoxications. These highly potential toxins are also known as the causative agent of puffer fish poisoning. A newly developed highly sensitive method for determination of TTXs based on hydrophilic interaction chromatography and mass-spectrometric detection is presented. TTX, anhydrotetrodotoxin, 11-deoxytetrodotoxin and trideoxytetrodotoxin were determined in separated tissues of Bangladeshi marine puffers, Takifugu oblongus. TTX was predominant in skin, muscle and liver, whereas trideoxytetrodotoxin preponderated in the ovary. The toxicity of the various tissues was determined by a mouse bioassay.
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