Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 35, Issue -, Pages 1191-1194Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0351191
Keywords
enterciendocrine cell; G-protein-coupled receptor (GPCR); gut hormone; intestinal glucose sensing; sodium/glucose co-transporter 1 (SGLT1); taste receptor
Categories
Funding
- NIDCD NIH HHS [R01 DC003155, R01 DC003055] Funding Source: Medline
Ask authors/readers for more resources
SGLT1 (Na+/glucose co-transporter 1) transports the dietary sugars, D-glucose and D-galactose, from the lumen of the intestine into enterocytes. SGLT1 regulation has important consequences for the provision of glucose to the respiring tissues and is therefore essential for maintaining glucose homoeostasis. SGLT1 expression is directly regulated in response to changes in the sugar content of the diet. To monitor these variations, there is a requirement for a glucose-sensing system located on the luminal membrane of gut cells. This short review focuses on recent findings on intestinal sugar sensing and the downstream mechanisms responsible for enhancement in SGLT1 expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available