Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 7, Issue 11, Pages 1108-1119Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707782331722
Keywords
privileged structures; pharmacophoric point; rational drug design; bioactive N-acylhydrazones derivatives
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Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.
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