Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 11, Pages 1759-1765Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.070720
Keywords
bisphosphonates; remodeling; toughness; biomechanics; osteoporosis
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Funding
- NCRR NIH HHS [C06 RR10601-01] Funding Source: Medline
- NIAMS NIH HHS [AR007581, AR047838] Funding Source: Medline
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Three years of daily alendronate treatment increases microdamage in vertebral bone but does not significantly increase it beyond levels of microdamage found after 1 yr of treatment. This suggests microdamage accumulation peaks during the early period of bisphosphonate treatment and does not continue to accumulate with longer periods of treatment.
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