Journal
AMINO ACIDS
Volume 46, Issue 8, Pages 1827-1838Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-014-1746-7
Keywords
Solid-phase peptide synthesis; Stepwise elongation; Side-chain anchoring; C-terminal acid peptide
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Funding
- UKZN
- NRF (South Africa)
- CICYT [CTQ2012-30930]
- Generalitat de Catalunya [2009SGR 1024]
- Institute for Research in Biomedicine (Spain)
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Here we review the strategies for the solid-phase synthesis of peptides starting from the side chain of the C-terminal amino acid. Furthermore, we provide experimental data to support that C-terminal and side-chain syntheses give similar results in terms of purity. However, the stability of the two bonds that anchor the peptide to the polymer may determine the overall yield and this should be considered for the large-scale production of peptides. In addition, resins/linkers which do not subject to side reactions can be preferred for some peptides.
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