Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 21, Pages 5876-5880Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.08.031
Keywords
design; synthesis; SARS 3CLpro; inhibitor; X-ray; structure
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Funding
- NIAID NIH HHS [P01 AI060915-01A10003, P01 AI060915] Funding Source: Medline
- NIGMS NIH HHS [R37 GM053386] Funding Source: Medline
- PHS HHS [P01 A1060915] Funding Source: Medline
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Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors are described. These inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor I bound to SARS-CoV 3CLpro. Incorporation of Boc-Ser as the P-4-ligand resulted in enhanced SARS-CoV 3CLpro inhibitory activity. Structural analysis of the inhibitor-bound X-ray structure revealed high binding affinity toward the enzyme. (c) 2007 Elsevier Ltd. All rights reserved.
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