Journal
DEVELOPMENT
Volume 134, Issue 21, Pages 3771-3780Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.006379
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Funding
- Medical Research Council [MC_U117570528] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [MC_U117570528] Funding Source: researchfish
- MRC [MC_U117570528] Funding Source: UKRI
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The vertebrate central nervous system contains a great diversity of neurons and glial cells, which are generated in the embryonic neural tube at specific times and positions. Several classes of transcription factors have been shown to control various steps in the differentiation of progenitor cells in the neural tube and to determine the identity of the cells produced. Recent evidence indicates that combinations of transcription factors of the homeodomain and basic helix- loop- helix families establish molecular codes that determine both where and when the different kinds of neurons and glial cells are generated.
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