Journal
AMINO ACIDS
Volume 43, Issue 5, Pages 2191-2198Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-012-1303-1
Keywords
Structure elucidation; Cyclic hexapeptide; Antibacterial activity
Categories
Funding
- National Key Basic Research Program (973 Program) [2010CB126100]
- Science and Technology Ministry of China
- National Natural Science Foundation of China [30971935]
- Postdoctoral Science Foundation of China [20100471644, 201104683]
- Program for New Century Excellent Talents in University from Education Ministry of China
Ask authors/readers for more resources
Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined by Marfey's method. NW-G10 (1) and NW-G11 (2) exhibited significant activity against Gram-positive bacteria, such as Bacillus cereus, Bacillus subtilis and Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), but they are not active against gram negatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available