Journal
AMINO ACIDS
Volume 44, Issue 3, Pages 1031-1037Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-012-1437-1
Keywords
Biginelli condensation; Bovine Serum Albumin; Biocatalysis; Sustainable Chemistry
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Funding
- CSIR, New Delhi
- IHBT Palampur [MLP0025]
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Bovine serum albumin (BSA) promoted simple and efficient one-pot procedure was developed for the direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones including potent mitotic kinesin Eg5 inhibitor monastrol under mild reaction conditions. The catalyst recyclability and gram scale synthesis have also been demonstrated to enhance the practical utility of process.
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